6m02

cryo-EM structure of human Pannexin 1 channelcryo-EM structure of human Pannexin 1 channel

Structural highlights

6m02 is a 7 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	PANX1, MRS1, UNQ2529/PRO6028 (HUMAN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PANX1_HUMAN] Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.^[1] ^[2]

References

↑ Vanden Abeele F, Bidaux G, Gordienko D, Beck B, Panchin YV, Baranova AV, Ivanov DV, Skryma R, Prevarskaya N. Functional implications of calcium permeability of the channel formed by pannexin 1. J Cell Biol. 2006 Aug 14;174(4):535-46. doi: 10.1083/jcb.200601115. PMID:16908669 doi:http://dx.doi.org/10.1083/jcb.200601115
↑ Bunse S, Schmidt M, Prochnow N, Zoidl G, Dermietzel R. Intracellular cysteine 346 is essentially involved in regulating Panx1 channel activity. J Biol Chem. 2010 Dec 3;285(49):38444-52. doi: 10.1074/jbc.M110.101014. Epub 2010, Sep 9. PMID:20829356 doi:http://dx.doi.org/10.1074/jbc.M110.101014

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OCA

[1] Vanden Abeele F, Bidaux G, Gordienko D, Beck B, Panchin YV, Baranova AV, Ivanov DV, Skryma R, Prevarskaya N. Functional implications of calcium permeability of the channel formed by pannexin 1. J Cell Biol. 2006 Aug 14;174(4):535-46. doi: 10.1083/jcb.200601115. PMID:16908669 doi:http://dx.doi.org/10.1083/jcb.200601115

[2] Bunse S, Schmidt M, Prochnow N, Zoidl G, Dermietzel R. Intracellular cysteine 346 is essentially involved in regulating Panx1 channel activity. J Biol Chem. 2010 Dec 3;285(49):38444-52. doi: 10.1074/jbc.M110.101014. Epub 2010, Sep 9. PMID:20829356 doi:http://dx.doi.org/10.1074/jbc.M110.101014

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6m02

cryo-EM structure of human Pannexin 1 channelcryo-EM structure of human Pannexin 1 channel

Structural highlights

Function

References

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6m02

cryo-EM structure of human Pannexin 1 channelcryo-EM structure of human Pannexin 1 channel

Structural highlights

Function

References

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