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Cryo-EM structure of the Drosophila CTP synthase substrate-bound filamentCryo-EM structure of the Drosophila CTP synthase substrate-bound filament
Structural highlights
FunctionPYRG_DROME Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). Isoform 1 is required for cytoophidium assembly in female germline cells.[1] References
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