6g0a

The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution.The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution.

Structural highlights

6g0a is a 3 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
NonStd Res:
Related:	6fwk
Activity:	DNA-directed DNA polymerase, with EC number 2.7.7.7
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[DPOE_YEAST] DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair.^[1]

References

↑ Shimizu K, Hashimoto K, Kirchner JM, Nakai W, Nishikawa H, Resnick MA, Sugino A. Fidelity of DNA polymerase epsilon holoenzyme from budding yeast Saccharomyces cerevisiae. J Biol Chem. 2002 Oct 4;277(40):37422-9. Epub 2002 Jul 17. PMID:12124389 doi:http://dx.doi.org/10.1074/jbc.M204476200

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OCA

[1] Shimizu K, Hashimoto K, Kirchner JM, Nakai W, Nishikawa H, Resnick MA, Sugino A. Fidelity of DNA polymerase epsilon holoenzyme from budding yeast Saccharomyces cerevisiae. J Biol Chem. 2002 Oct 4;277(40):37422-9. Epub 2002 Jul 17. PMID:12124389 doi:http://dx.doi.org/10.1074/jbc.M204476200

[1]

6g0a

The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution.The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution.

Structural highlights

Function

References

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6g0a

The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution.The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution.

Structural highlights

Function

References

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