Structural highlights
6cz9 is a 4 chain structure with sequence from Shewanella sp. ANA-3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 1.8Å |
| Ligands: | , , , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
ARRA_SHESA Component of the arsenate respiratory reductase (Arr) complex, which catalyzes the reduction of arsenate (As(V)) to arsenite (As(III)) (PubMed:12939408, PubMed:17951391, PubMed:30104376). ArrA is the arsenate-binding subunit (PubMed:30104376). The periplasmic localization of this complex may allow the cell to couple arsenate reduction to energy production before arsenate can be transported to the cell cytoplasm and enter the ars detoxification pathway, an energy-requiring process (PubMed:17951391).[1] [2] [3]
References
- ↑ Saltikov CW, Newman DK. Genetic identification of a respiratory arsenate reductase. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10983-8. PMID:12939408 doi:10.1073/pnas.1834303100
- ↑ Malasarn D, Keeffe JR, Newman DK. Characterization of the arsenate respiratory reductase from Shewanella sp. strain ANA-3. J Bacteriol. 2008 Jan;190(1):135-42. PMID:17951391 doi:10.1128/JB.01110-07
- ↑ Glasser NR, Oyala PH, Osborne TH, Santini JM, Newman DK. Structural and mechanistic analysis of the arsenate respiratory reductase provides insight into environmental arsenic transformations. Proc Natl Acad Sci U S A. 2018 Aug 13. pii: 1807984115. doi:, 10.1073/pnas.1807984115. PMID:30104376 doi:http://dx.doi.org/10.1073/pnas.1807984115