6bhx

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B. subtilis SsbA with DNAB. subtilis SsbA with DNA

Structural highlights

6bhx is a 5 chain structure with sequence from Bacillus subtilis subsp. subtilis str. 168 and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.936Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SSBA_BACSU Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism (PubMed:21170359). Has a 20-fold higher affinity for ssDNA than SsbB; SsbA and DprA activate the homologuos DNA strand exchange function of RecA-ATP (PubMed:25138221).[1] [2]

See Also

References

  1. ↑ Yadav T, Carrasco B, Serrano E, Alonso JC. Roles of Bacillus subtilis DprA and SsbA in RecA-mediated genetic recombination. J Biol Chem. 2014 Oct 3;289(40):27640-52. doi: 10.1074/jbc.M114.577924. Epub 2014, Aug 19. PMID:25138221 doi:http://dx.doi.org/10.1074/jbc.M114.577924
  2. ↑ Costes A, Lecointe F, McGovern S, Quevillon-Cheruel S, Polard P. The C-terminal domain of the bacterial SSB protein acts as a DNA maintenance hub at active chromosome replication forks. PLoS Genet. 2010 Dec 9;6(12):e1001238. doi: 10.1371/journal.pgen.1001238. PMID:21170359 doi:http://dx.doi.org/10.1371/journal.pgen.1001238

6bhx, resolution 2.94Å

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OCA
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