5uqu

Crystal structure of mutant 2-methylcitrate synthase (mcsAG352A) from Aspergillus fumigatusCrystal structure of mutant 2-methylcitrate synthase (mcsAG352A) from Aspergillus fumigatus

Structural highlights

5uqu is a 2 chain structure with sequence from Aspergillus fumigatus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.7Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PRPC_ASPFM Component of the methylcitrate cycle that catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate. Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism. Has also citrate synthase activity using as substrates acetyl-CoA and oxaloacetate. May play a role in virulence.^[1]

References

↑ Maerker C, Rohde M, Brakhage AA, Brock M. Methylcitrate synthase from Aspergillus fumigatus. Propionyl-CoA affects polyketide synthesis, growth and morphology of conidia. FEBS J. 2005 Jul;272(14):3615-30. doi: 10.1111/j.1742-4658.2005.04784.x. PMID:16008561 doi:http://dx.doi.org/10.1111/j.1742-4658.2005.04784.x

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OCA

[1] Maerker C, Rohde M, Brakhage AA, Brock M. Methylcitrate synthase from Aspergillus fumigatus. Propionyl-CoA affects polyketide synthesis, growth and morphology of conidia. FEBS J. 2005 Jul;272(14):3615-30. doi: 10.1111/j.1742-4658.2005.04784.x. PMID:16008561 doi:http://dx.doi.org/10.1111/j.1742-4658.2005.04784.x

[1]

5uqu

Crystal structure of mutant 2-methylcitrate synthase (mcsAG352A) from Aspergillus fumigatusCrystal structure of mutant 2-methylcitrate synthase (mcsAG352A) from Aspergillus fumigatus

Structural highlights

Function

See Also

References

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5uqu

Crystal structure of mutant 2-methylcitrate synthase (mcsAG352A) from Aspergillus fumigatusCrystal structure of mutant 2-methylcitrate synthase (mcsAG352A) from Aspergillus fumigatus

Structural highlights

Function

See Also

References

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