5ou7

Crystal structure of the Glycoprotein VI loop truncation mutant PAVS-PAPYKNCrystal structure of the Glycoprotein VI loop truncation mutant PAVS-PAPYKN

Structural highlights 5ou7 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.9Å Ligands: , , , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease GPVI_HUMAN Bleeding diathesis due to glycoprotein VI deficiency. The disease is caused by mutations affecting the gene represented in this entry. Function GPVI_HUMAN Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.

spinqualitylabelsall models 5ou7, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image