5j5c

Crystal structure of ARL1-GTP and DCB domain of BIG1 complexCrystal structure of ARL1-GTP and DCB domain of BIG1 complex

Structural highlights

5j5c is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.4Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ARL1_HUMAN GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus.^[1]

References

↑ Hong JX, Lee FJ, Patton WA, Lin CY, Moss J, Vaughan M. Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1). J Biol Chem. 1998 Jun 19;273(25):15872-6. PMID:9624189

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OCA

[1] Hong JX, Lee FJ, Patton WA, Lin CY, Moss J, Vaughan M. Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1). J Biol Chem. 1998 Jun 19;273(25):15872-6. PMID:9624189

[1]

5j5c

Crystal structure of ARL1-GTP and DCB domain of BIG1 complexCrystal structure of ARL1-GTP and DCB domain of BIG1 complex

Structural highlights

Function

References

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5j5c

Crystal structure of ARL1-GTP and DCB domain of BIG1 complexCrystal structure of ARL1-GTP and DCB domain of BIG1 complex

Structural highlights

Function

References

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