5im1
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Tobacco 5-epi-aristolochene synthase without buffer molecule in the active siteTobacco 5-epi-aristolochene synthase without buffer molecule in the active site
Structural highlights
Function5EAS_TOBAC Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene. |
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