5hz3

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Plant peptide hormone receptor RGFR1 in complex with RGFR5Plant peptide hormone receptor RGFR1 in complex with RGFR5

Structural highlights

5hz3 is a 2 chain structure with sequence from Arabidopsis and Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.86Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RGI3_ARATH Together with RGI1, RGI2, RGI4 and RGI5, acts as receptor of RGF peptides (e.g. RGF1, GLV5/CLEL1/RGF2, GLV7/CLEL3/RGF3, GLV3/RGF4, GLV10/CLEL7/RGF5 and RGF10/CLELN), peptide hormones which maintain the postembryonic root stem cell niche by regulating the expression levels and patterns of the transcription factor PLETHORA (PLT, e.g. PLT1 and PLT2) (PubMed:27229311, PubMed:27229312, PubMed:27001831). Links RGF peptides signal with their downstream components (PubMed:27229311, PubMed:27001831).[1] [2] [3]

References

  1. Shinohara H, Mori A, Yasue N, Sumida K, Matsubayashi Y. Identification of three LRR-RKs involved in perception of root meristem growth factor in Arabidopsis. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3897-902. PMID:27001831 doi:10.1073/pnas.1522639113
  2. Song W, Liu L, Wang J, Wu Z, Zhang H, Tang J, Lin G, Wang Y, Wen X, Li W, Han Z, Guo H, Chai J. Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth. Cell Res. 2016 Jun;26(6):674-85. doi: 10.1038/cr.2016.62. Epub 2016 May 27. PMID:27229311 doi:http://dx.doi.org/10.1038/cr.2016.62
  3. Ou Y, Lu X, Zi Q, Xun Q, Zhang J, Wu Y, Shi H, Wei Z, Zhao B, Zhang X, He K, Gou X, Li C, Li J. RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor 1 in Arabidopsis thaliana. Cell Res. 2016 Jun;26(6):686-98. PMID:27229312 doi:10.1038/cr.2016.63

5hz3, resolution 2.86Å

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OCA