5gvx

Structural insight into dephosphorylation by Trehalose 6-phosphate Phosphatase (OtsB2) from Mycobacterium TuberculosisStructural insight into dephosphorylation by Trehalose 6-phosphate Phosphatase (OtsB2) from Mycobacterium Tuberculosis

5gvx is a 1 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.596Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

OTSB_MYCTU Removes the phosphate from trehalose 6-phosphate to produce free trehalose.^[1] ^[2]

↑ Edavana VK, Pastuszak I, Carroll JD, Thampi P, Abraham EC, Elbein AD. Cloning and expression of the trehalose-phosphate phosphatase of Mycobacterium tuberculosis: comparison to the enzyme from Mycobacterium smegmatis. Arch Biochem Biophys. 2004 Jun 15;426(2):250-7. PMID:15158675 doi:http://dx.doi.org/10.1016/j.abb.2004.02.014
↑ Murphy HN, Stewart GR, Mischenko VV, Apt AS, Harris R, McAlister MS, Driscoll PC, Young DB, Robertson BD. The OtsAB pathway is essential for trehalose biosynthesis in Mycobacterium tuberculosis. J Biol Chem. 2005 Apr 15;280(15):14524-9. Epub 2005 Feb 9. PMID:15703182 doi:http://dx.doi.org/10.1074/jbc.M414232200