4zft

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Catalytic domain of Sst2 F403W mutant bound to ubiquitinCatalytic domain of Sst2 F403W mutant bound to ubiquitin

Structural highlights

4zft is a 4 chain structure with sequence from Homo sapiens and Schizosaccharomyces pombe 972h-. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.304Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SST2_SCHPO Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in the multivesicular body (MVB) sorting pathway. Required for ubiquitin-dependent sorting of proteins into the endosome and subsequent trafficking to the vacuole. May regulate MVB sorting through deubiquitination of ubiquitinated ESCRT proteins.[1]

See Also

References

  1. ↑ Iwaki T, Onishi M, Ikeuchi M, Kita A, Sugiura R, Giga-Hama Y, Fukui Y, Takegawa K. Essential roles of class E Vps proteins for sorting into multivesicular bodies in Schizosaccharomyces pombe. Microbiology. 2007 Aug;153(Pt 8):2753-64. PMID:17660439 doi:http://dx.doi.org/10.1099/mic.0.2007/006072-0

4zft, resolution 2.30Å

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OCA
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