4pw2

From Proteopedia
Jump to navigation Jump to search

Crystal structure of D-glucuronyl C5 epimeraseCrystal structure of D-glucuronyl C5 epimerase

Structural highlights

4pw2 is a 1 chain structure with sequence from Danio rerio. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLCEB_DANRE Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains (PubMed:16156897, PubMed:25568314). Plays a role in dorso-ventral axis specification during early development, together with glcea, where it may potentiate signaling via the BMP pathway (PubMed:16156897).[1] [2]

References

  1. ↑ Ghiselli G, Farber SA. D-glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafish. BMC Dev Biol. 2005 Sep 12;5:19. PMID:16156897 doi:10.1186/1471-213X-5-19
  2. ↑ Qin Y, Ke J, Gu X, Fang J, Wang W, Cong Q, Li J, Tan J, Brunzelle JS, Zhang C, Jiang Y, Melcher K, Li JP, Xu HE, Ding K. Structural and functional study of D-glucuronyl C5-epimerase. J Biol Chem. 2015 Jan 7. pii: jbc.M114.602201. PMID:25568314 doi:http://dx.doi.org/10.1074/jbc.M114.602201

4pw2, resolution 1.90Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=4pw2&oldid=4075956"