4p5a
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Crystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi bound with 5-Br UMPCrystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi bound with 5-Br UMP
Structural highlights
FunctionC1IC19_9ACTN Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.[HAMAP-Rule:MF_01408] See Also |
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