4oep

Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin1 C-terminal tailCrystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin1 C-terminal tail

Structural highlights

4oep is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.35Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ZO1_HUMAN The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.^[1]

References

↑ Huo L, Wen W, Wang R, Kam C, Xia J, Feng W, Zhang M. Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration. EMBO J. 2011 Feb 16;30(4):665-78. Epub 2011 Jan 14. PMID:21240187 doi:10.1038/emboj.2010.353

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OCA

[1] Huo L, Wen W, Wang R, Kam C, Xia J, Feng W, Zhang M. Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration. EMBO J. 2011 Feb 16;30(4):665-78. Epub 2011 Jan 14. PMID:21240187 doi:10.1038/emboj.2010.353

[1]

4oep

Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin1 C-terminal tailCrystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin1 C-terminal tail

Structural highlights

Function

References

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4oep

Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin1 C-terminal tailCrystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin1 C-terminal tail

Structural highlights

Function

References

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