4m7l

Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragmentCrystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment

Structural highlights

4m7l is a 3 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.4Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TF_HUMAN Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.^[1]

References

↑ Bogdanov VY, Balasubramanian V, Hathcock J, Vele O, Lieb M, Nemerson Y. Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Nat Med. 2003 Apr;9(4):458-62. Epub 2003 Mar 24. PMID:12652293 doi:10.1038/nm841

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OCA

[1] Bogdanov VY, Balasubramanian V, Hathcock J, Vele O, Lieb M, Nemerson Y. Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Nat Med. 2003 Apr;9(4):458-62. Epub 2003 Mar 24. PMID:12652293 doi:10.1038/nm841

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4m7l

Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragmentCrystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment

Structural highlights

Function

See Also

References

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4m7l

Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragmentCrystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment

Structural highlights

Function

See Also

References

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