4l6w

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Carboxyltransferase subunit (AccD6) of Mycobacterium tuberculosis acetyl-CoA carboxylaseCarboxyltransferase subunit (AccD6) of Mycobacterium tuberculosis acetyl-CoA carboxylase

Structural highlights

4l6w is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.95Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ACCD6_MYCTU Component of a biotin-dependent acyl-CoA carboxylase complex. This subunit transfers the CO2 from carboxybiotin to the CoA ester substrate (PubMed:17114269). When associated with the alpha3 subunit AccA3, is involved in the carboxylation of acetyl-CoA and propionyl-CoA, with a preference for acetyl-CoA (PubMed:17114269).[1]

References

  1. Daniel J, Oh TJ, Lee CM, Kolattukudy PE. AccD6, a member of the Fas II locus, is a functional carboxyltransferase subunit of the acyl-coenzyme A carboxylase in Mycobacterium tuberculosis. J Bacteriol. 2007 Feb;189(3):911-7. doi: 10.1128/JB.01019-06. Epub 2006 Nov 17. PMID:17114269 doi:http://dx.doi.org/10.1128/JB.01019-06

4l6w, resolution 1.95Å

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OCA