4jv2

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Ternary complex of gamma-OHPDG adduct modified dna with dna (-1 primer) polymerase iv and incoming datpTernary complex of gamma-OHPDG adduct modified dna with dna (-1 primer) polymerase iv and incoming datp

Structural highlights

4jv2 is a 3 chain structure with sequence from Saccharolobus solfataricus P2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.74Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DPO4_SACS2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.

See Also

4jv2, resolution 2.74Å

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OCA