4jv2
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Ternary complex of gamma-OHPDG adduct modified dna with dna (-1 primer) polymerase iv and incoming datpTernary complex of gamma-OHPDG adduct modified dna with dna (-1 primer) polymerase iv and incoming datp
Structural highlights
FunctionDPO4_SACS2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis. See Also |
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