4izd

Crystal structure of DmdD E121A in complex with MMPA-CoACrystal structure of DmdD E121A in complex with MMPA-CoA

Structural highlights

4izd is a 2 chain structure with sequence from Ruegeria pomeroyi DSS-3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.8Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DMDD_RUEPO Involved in the assimilation of dimethylsulphoniopropionate (DMSP), an important compound in the fixation of carbon in marine phytoplankton, by catalyzing both the hydration and the hydrolysis of 3-(methylthio)acryloyl-CoA (MTA-CoA) to acetaldehyde, CO2, MeSH, and CoA (PubMed:21562561, PubMed:23704947).^[1] ^[2]

References

↑ Reisch CR, Stoudemayer MJ, Varaljay VA, Amster IJ, Moran MA, Whitman WB. Novel pathway for assimilation of dimethylsulphoniopropionate widespread in marine bacteria. Nature. 2011 May 12;473(7346):208-11. doi: 10.1038/nature10078. PMID:21562561 doi:http://dx.doi.org/10.1038/nature10078
↑ Tan D, Crabb WM, Whitman WB, Tong L. Crystal Structure of DmdD, a Crotonase Superfamily Enzyme That Catalyzes the Hydration and Hydrolysis of Methylthioacryloyl-CoA. PLoS One. 2013 May 21;8(5):e63870. doi: 10.1371/journal.pone.0063870. Print 2013. PMID:23704947 doi:10.1371/journal.pone.0063870

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OCA

[1] Reisch CR, Stoudemayer MJ, Varaljay VA, Amster IJ, Moran MA, Whitman WB. Novel pathway for assimilation of dimethylsulphoniopropionate widespread in marine bacteria. Nature. 2011 May 12;473(7346):208-11. doi: 10.1038/nature10078. PMID:21562561 doi:http://dx.doi.org/10.1038/nature10078

[2] Tan D, Crabb WM, Whitman WB, Tong L. Crystal Structure of DmdD, a Crotonase Superfamily Enzyme That Catalyzes the Hydration and Hydrolysis of Methylthioacryloyl-CoA. PLoS One. 2013 May 21;8(5):e63870. doi: 10.1371/journal.pone.0063870. Print 2013. PMID:23704947 doi:10.1371/journal.pone.0063870

[1]

[2]

4izd

Crystal structure of DmdD E121A in complex with MMPA-CoACrystal structure of DmdD E121A in complex with MMPA-CoA

Structural highlights

Function

See Also

References

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4izd

Crystal structure of DmdD E121A in complex with MMPA-CoACrystal structure of DmdD E121A in complex with MMPA-CoA

Structural highlights

Function

See Also

References

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