4gu3

Crystal structure of the T1L reovirus attachment protein sigma1 in complex with the GM2 glycanCrystal structure of the T1L reovirus attachment protein sigma1 in complex with the GM2 glycan

Structural highlights 4gu3 is a 3 chain structure with sequence from Mammalian orthoreovirus 1 Lang. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.6Å Ligands: , , , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SIGM1_REOVL Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity). See Also Virus coat proteins 3D structures

spinqualitylabelsall models 4gu3, resolution 3.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image