4fmw

Crystal structure of methyltransferase domain of human RNA (guanine-9-) methyltransferase domain containing protein 2Crystal structure of methyltransferase domain of human RNA (guanine-9-) methyltransferase domain containing protein 2

Structural highlights

4fmw is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

TM10A_HUMAN Primary microcephaly-mild intellectual disability-young-onset diabetes syndrome. The disease is caused by mutations affecting the gene represented in this entry.

Function

TM10A_HUMAN RNA methyltransferase.^[1]

References

↑ Gillis D, Krishnamohan A, Yaacov B, Shaag A, Jackman JE, Elpeleg O. TRMT10A dysfunction is associated with abnormalities in glucose homeostasis, short stature and microcephaly. J Med Genet. 2014 Sep;51(9):581-6. doi: 10.1136/jmedgenet-2014-102282. Epub 2014 , Jul 22. PMID:25053765 doi:http://dx.doi.org/10.1136/jmedgenet-2014-102282

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OCA

[1] Gillis D, Krishnamohan A, Yaacov B, Shaag A, Jackman JE, Elpeleg O. TRMT10A dysfunction is associated with abnormalities in glucose homeostasis, short stature and microcephaly. J Med Genet. 2014 Sep;51(9):581-6. doi: 10.1136/jmedgenet-2014-102282. Epub 2014 , Jul 22. PMID:25053765 doi:http://dx.doi.org/10.1136/jmedgenet-2014-102282

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