4f9c

Human CDC7 kinase in complex with DBF4 and XL413Human CDC7 kinase in complex with DBF4 and XL413

Structural highlights

4f9c is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.08Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CDC7_HUMAN Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.^[1]

References

↑ Montagnoli A, Bosotti R, Villa F, Rialland M, Brotherton D, Mercurio C, Berthelsen J, Santocanale C. Drf1, a novel regulatory subunit for human Cdc7 kinase. EMBO J. 2002 Jun 17;21(12):3171-81. PMID:12065429 doi:http://dx.doi.org/10.1093/emboj/cdf290

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OCA

[1] Montagnoli A, Bosotti R, Villa F, Rialland M, Brotherton D, Mercurio C, Berthelsen J, Santocanale C. Drf1, a novel regulatory subunit for human Cdc7 kinase. EMBO J. 2002 Jun 17;21(12):3171-81. PMID:12065429 doi:http://dx.doi.org/10.1093/emboj/cdf290

[1]

4f9c

Human CDC7 kinase in complex with DBF4 and XL413Human CDC7 kinase in complex with DBF4 and XL413

Structural highlights

Function

References

Contents

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4f9c

Human CDC7 kinase in complex with DBF4 and XL413Human CDC7 kinase in complex with DBF4 and XL413

Structural highlights

Function

References

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