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Crystal Structure of Anthrax Protective Antigen K446M Mutant to 1.91-A ResolutionCrystal Structure of Anthrax Protective Antigen K446M Mutant to 1.91-A Resolution
Structural highlights
FunctionPAG_BACAN One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax. |
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