4e15

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Crystal structure of kynurenine formamidase conjugated with an inhibitorCrystal structure of kynurenine formamidase conjugated with an inhibitor

Structural highlights

4e15 is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.5Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KFA_DROME Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Required for elimination of toxic metabolites.[HAMAP-Rule:MF_03014][1] [2]

References

  1. ↑ Han Q, Robinson H, Li J. Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster. Biochem J. 2012 Jun 12. PMID:22690733 doi:10.1042/BJ20120416
  2. ↑ Moore GP, Sullivan DT. Biochemical and genetic characterization of kynurenine formamidase from Drosophila melanogaster. Biochem Genet. 1978 Aug;16(7-8):619-34. PMID:83140

4e15, resolution 1.50Å

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OCA
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