4dpm

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Structure of malonyl-coenzyme A reductase from crenarchaeota in complex with CoAStructure of malonyl-coenzyme A reductase from crenarchaeota in complex with CoA

Structural highlights

4dpm is a 6 chain structure with sequence from Sulfurisphaera tokodaii str. 7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MCR_SULTO Catalyzes the reduction of malonyl-CoA to malonate semialdehyde, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutyrate cycles. Can also use succinyl-CoA and succinate semialdehyde as substrates but at a lower rate than malonyl-CoA.[1]

References

  1. Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hugler M, Fuchs G. Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp. J Bacteriol. 2006 Dec;188(24):8551-9. Epub 2006 Oct 13. PMID:17041055 doi:http://dx.doi.org/10.1128/JB.00987-06

4dpm, resolution 2.30Å

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OCA