4djg

Crystal structure of the coiled-coil 1 domain of actin-binding protein SCAB1Crystal structure of the coiled-coil 1 domain of actin-binding protein SCAB1

Structural highlights

4djg is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.9Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SCAB1_ARATH Plant-specific actin binding protein that bundles and stabilizes microfilaments (MFs). Has no nucleation or capping activity. Regulates MF reorganization during stomatal closure. The binding to F-actin is insensitive to Ca(2+) and pH. Binds weakly to inositol phosphates (PubMed:22356912).^[1] ^[2]

References

↑ Zhao Y, Zhao S, Mao T, Qu X, Cao W, Zhang L, Zhang W, He L, Li S, Ren S, Zhao J, Zhu G, Huang S, Ye K, Yuan M, Guo Y. The plant-specific actin binding protein SCAB1 stabilizes actin filaments and regulates stomatal movement in Arabidopsis. Plant Cell. 2011 Jun;23(6):2314-30. doi: 10.1105/tpc.111.086546. Epub 2011 Jun, 30. PMID:21719691 doi:http://dx.doi.org/10.1105/tpc.111.086546
↑ Zhang W, Zhao Y, Guo Y, Ye K. Plant actin-binding protein SCAB1 is dimeric actin cross-linker with atypical pleckstrin homology domain. J Biol Chem. 2012 Apr 6;287(15):11981-90. Epub 2012 Feb 22. PMID:22356912 doi:10.1074/jbc.M111.338525

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OCA

[1] Zhao Y, Zhao S, Mao T, Qu X, Cao W, Zhang L, Zhang W, He L, Li S, Ren S, Zhao J, Zhu G, Huang S, Ye K, Yuan M, Guo Y. The plant-specific actin binding protein SCAB1 stabilizes actin filaments and regulates stomatal movement in Arabidopsis. Plant Cell. 2011 Jun;23(6):2314-30. doi: 10.1105/tpc.111.086546. Epub 2011 Jun, 30. PMID:21719691 doi:http://dx.doi.org/10.1105/tpc.111.086546

[2] Zhang W, Zhao Y, Guo Y, Ye K. Plant actin-binding protein SCAB1 is dimeric actin cross-linker with atypical pleckstrin homology domain. J Biol Chem. 2012 Apr 6;287(15):11981-90. Epub 2012 Feb 22. PMID:22356912 doi:10.1074/jbc.M111.338525

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4djg

Crystal structure of the coiled-coil 1 domain of actin-binding protein SCAB1Crystal structure of the coiled-coil 1 domain of actin-binding protein SCAB1

Structural highlights

Function

References

Contents

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4djg

Crystal structure of the coiled-coil 1 domain of actin-binding protein SCAB1Crystal structure of the coiled-coil 1 domain of actin-binding protein SCAB1

Structural highlights

Function

References

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