4ayr

Structure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31 in complex with noeuromycinStructure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31 in complex with noeuromycin

Structural highlights 4ayr is a 1 chain structure with sequence from Caulobacter sp. K31. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.1Å Ligands: , , , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function B0SWV2_CAUSK Publication Abstract from PubMed Mannosides in the southern hemisphere: Conformational analysis of enzymatic mannoside hydrolysis informs strategies for enzyme inhibition and inspires solutions to mannoside synthesis. Atomic resolution structures along the reaction coordinate of an inverting alpha-mannosidase show how the enzyme distorts the substrate and transition state. QM/MM calculations reveal how the free energy landscape of isolated alpha-D-mannose is molded on enzyme to only allow one conformationally accessible reaction coordinate. The reaction coordinate of a bacterial GH47 alpha-mannosidase: a combined quantum mechanical and structural approach.,Thompson AJ, Dabin J, Iglesias-Fernandez J, Ardevol A, Dinev Z, Williams SJ, Bande O, Siriwardena A, Moreland C, Hu TC, Smith DK, Gilbert HJ, Rovira C, Davies GJ Angew Chem Int Ed Engl. 2012 Oct 29;51(44):10997-1001. doi:, 10.1002/anie.201205338. Epub 2012 Sep 26. PMID:23012075 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Mannosidase 3D structures

spinqualitylabelsall models 4ayr, resolution 1.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image