3ww0

Crystal structure of F97A mutant, a new nuclear transport receptor of Hsp70Crystal structure of F97A mutant, a new nuclear transport receptor of Hsp70

Structural highlights

3ww0 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.5Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HIKES_HUMAN Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.^[1]

References

↑ Kose S, Furuta M, Imamoto N. Hikeshi, a nuclear import carrier for Hsp70s, protects cells from heat shock-induced nuclear damage. Cell. 2012 Apr 27;149(3):578-89. doi: 10.1016/j.cell.2012.02.058. PMID:22541429 doi:http://dx.doi.org/10.1016/j.cell.2012.02.058

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OCA

[1] Kose S, Furuta M, Imamoto N. Hikeshi, a nuclear import carrier for Hsp70s, protects cells from heat shock-induced nuclear damage. Cell. 2012 Apr 27;149(3):578-89. doi: 10.1016/j.cell.2012.02.058. PMID:22541429 doi:http://dx.doi.org/10.1016/j.cell.2012.02.058

[1]

3ww0

Crystal structure of F97A mutant, a new nuclear transport receptor of Hsp70Crystal structure of F97A mutant, a new nuclear transport receptor of Hsp70

Structural highlights

Function

References

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3ww0

Crystal structure of F97A mutant, a new nuclear transport receptor of Hsp70Crystal structure of F97A mutant, a new nuclear transport receptor of Hsp70

Structural highlights

Function

References

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