3vib

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Structural basis for multidrug recognition and antimicrobial resistance by MTRR, an efflux pump regulator from Neisseria GonorrhoeaeStructural basis for multidrug recognition and antimicrobial resistance by MTRR, an efflux pump regulator from Neisseria Gonorrhoeae

Structural highlights

3vib is a 4 chain structure with sequence from Neisseria gonorrhoeae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MTRR_NEIGO Controls the permeability of the cell envelope to hydrophobic compounds such as antibiotics and detergents (PubMed:8196548). Represses transcription of the mtrCDE-encoded efflux pump by binding within the mtrCDE promoter (PubMed:9209024, PubMed:23221802). Also negatively regulates the expression of farR, by binding to its promoter region, leading indirectly to the positive regulation of expression of the farAB-encoded efflux pump (PubMed:14645274).[1] [2] [3] [4]

References

  1. ↑ Lee EH, Rouquette-Loughlin C, Folster JP, Shafer WM. FarR regulates the farAB-encoded efflux pump of Neisseria gonorrhoeae via an MtrR regulatory mechanism. J Bacteriol. 2003 Dec;185(24):7145-52. doi: 10.1128/jb.185.24.7145-7152.2003. PMID:14645274 doi:http://dx.doi.org/10.1128/jb.185.24.7145-7152.2003
  2. ↑ Zalucki YM, Dhulipala V, Shafer WM. Dueling regulatory properties of a transcriptional activator (MtrA) and repressor (MtrR) that control efflux pump gene expression in Neisseria gonorrhoeae. MBio. 2012 Dec 4;3(6):e00446-12. doi: 10.1128/mBio.00446-12. PMID:23221802 doi:http://dx.doi.org/10.1128/mBio.00446-12
  3. ↑ Pan W, Spratt BG. Regulation of the permeability of the gonococcal cell envelope by the mtr system. Mol Microbiol. 1994 Feb;11(4):769-75. doi: 10.1111/j.1365-2958.1994.tb00354.x. PMID:8196548 doi:http://dx.doi.org/10.1111/j.1365-2958.1994.tb00354.x
  4. ↑ Lucas CE, Balthazar JT, Hagman KE, Shafer WM. The MtrR repressor binds the DNA sequence between the mtrR and mtrC genes of Neisseria gonorrhoeae. J Bacteriol. 1997 Jul;179(13):4123-8. doi: 10.1128/jb.179.13.4123-4128.1997. PMID:9209024 doi:http://dx.doi.org/10.1128/jb.179.13.4123-4128.1997

3vib, resolution 2.40Å

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OCA
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