3vco

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Schistosoma mansoni Dihydrofolate reductaseSchistosoma mansoni Dihydrofolate reductase

Structural highlights

3vco is a 1 chain structure with sequence from Schistosoma mansoni. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.946Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DYR_SCHMA Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[1]

See Also

References

  1. ↑ Serrao VHB, Romanello L, Cassago A, de Souza JRT, Cheleski J, DeMarco R, Brandao-Neto J, Pereira HD. Structure and kinetics assays of recombinant Schistosoma mansoni dihydrofolate reductase. Acta Trop. 2017 Jun;170:190-196. doi: 10.1016/j.actatropica.2017.03.007. Epub, 2017 Mar 11. PMID:28288799 doi:http://dx.doi.org/10.1016/j.actatropica.2017.03.007

3vco, resolution 1.95Å

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OCA
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