3sl2

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ATP Forms a Stable Complex with the Essential Histidine Kinase WalK (YycG) DomainATP Forms a Stable Complex with the Essential Histidine Kinase WalK (YycG) Domain

Structural highlights

3sl2 is a 1 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.61Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

WALK_BACSU Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Phosphorylates WalR.[1] [2] [3] [4] [5]

References

  1. Fukuchi K, Kasahara Y, Asai K, Kobayashi K, Moriya S, Ogasawara N. The essential two-component regulatory system encoded by yycF and yycG modulates expression of the ftsAZ operon in Bacillus subtilis. Microbiology. 2000 Jul;146 ( Pt 7):1573-83. PMID:10878122
  2. Yamamoto K, Kitayama T, Minagawa S, Watanabe T, Sawada S, Okamoto T, Utsumi R. Antibacterial agents that inhibit histidine protein kinase YycG of Bacillus subtilis. Biosci Biotechnol Biochem. 2001 Oct;65(10):2306-10. PMID:11758928 doi:10.1271/bbb.65.2306
  3. Howell A, Dubrac S, Andersen KK, Noone D, Fert J, Msadek T, Devine K. Genes controlled by the essential YycG/YycF two-component system of Bacillus subtilis revealed through a novel hybrid regulator approach. Mol Microbiol. 2003 Sep;49(6):1639-55. PMID:12950927 doi:10.1046/j.1365-2958.2003.03661.x
  4. Bisicchia P, Noone D, Lioliou E, Howell A, Quigley S, Jensen T, Jarmer H, Devine KM. The essential YycFG two-component system controls cell wall metabolism in Bacillus subtilis. Mol Microbiol. 2007 Jul;65(1):180-200. PMID:17581128 doi:http://dx.doi.org/MMI5782
  5. Fabret C, Hoch JA. A two-component signal transduction system essential for growth of Bacillus subtilis: implications for anti-infective therapy. J Bacteriol. 1998 Dec;180(23):6375-83. PMID:9829949

3sl2, resolution 1.61Å

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