Structure of Mycobacterium tuberculosis DnaA-DBD in complex with box1 DNAStructure of Mycobacterium tuberculosis DnaA-DBD in complex with box1 DNA

Structural highlights

3pvv is a 6 chain structure with sequence from Mycobacterium tuberculosis H37Ra. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DNAA_MYCTA Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.[HAMAP-Rule:MF_00377]

See Also

3pvv, resolution 2.00Å

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OCA