3nss

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The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active sitesThe 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active sites

Structural highlights

3nss is a 2 chain structure with sequence from Influenza A virus (A/California/04/2009(H1N1)). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.902Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

C3W5S3_I09A0

Publication Abstract from PubMed

Influenza A virus neuraminidase can be classified into groups 1 and 2 on the basis of its primary structure. The main structural feature of group 1 neuraminidase is an extra cavity in the active site, the 150-cavity. Here we present the crystal structure of neuraminidase from the 2009 pandemic H1N1 influenza strain. In contrast to other characterized N1 neuraminidases, which are all members of group 1, 2009 H1N1 neuraminidase does not have a 150-cavity.

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site.,Li Q, Qi J, Zhang W, Vavricka CJ, Shi Y, Wei J, Feng E, Shen J, Chen J, Liu D, He J, Yan J, Liu H, Jiang H, Teng M, Li X, Gao GF Nat Struct Mol Biol. 2010 Oct;17(10):1266-8. Epub 2010 Sep 19. PMID:20852645[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. Li Q, Qi J, Zhang W, Vavricka CJ, Shi Y, Wei J, Feng E, Shen J, Chen J, Liu D, He J, Yan J, Liu H, Jiang H, Teng M, Li X, Gao GF. The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site. Nat Struct Mol Biol. 2010 Oct;17(10):1266-8. Epub 2010 Sep 19. PMID:20852645 doi:10.1038/nsmb.1909

3nss, resolution 1.90Å

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OCA