Crystal structure of the N-terminal domains of the ubiquitin specific peptidase 4 (USP4)Crystal structure of the N-terminal domains of the ubiquitin specific peptidase 4 (USP4)
Structural highlights
3jyu is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
UBP4_MOUSE Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (By similarity). Deubiquitinates PDPK1 (By similarity). Deubiquitinates TRIM21 (By similarity). Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (By similarity). Deubiquitinates HAS2 (By similarity). Deubiquitinates RHEB in response to EGF signaling, promoting mTORC1 signaling (By similarity). May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (By similarity). This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP (By similarity). May also play a role in the regulation of quality control in the ER (By similarity).[UniProtKB:Q13107]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
