3j05

Three-dimensional structure of Dengue virus serotype 1 complexed with HMAb 14c10 FabThree-dimensional structure of Dengue virus serotype 1 complexed with HMAb 14c10 Fab

3j05, resolution 7.00Å Show:Asymmetric Unit Biological Assembly Structural highlights 3j05 is a 3 chain structure with sequence from Dengue virus 1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 7Å Experimental data: Check Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q689G3_9FLAV Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS013754_004_099774]