3e9v

Crystal structure of human B-cell Translocation Gene 2 (BTG2)Crystal structure of human B-cell Translocation Gene 2 (BTG2)

Structural highlights

3e9v is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.7Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

BTG2_HUMAN Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Anti-proliferative protein. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.^[1] ^[2] ^[3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Morel AP, Sentis S, Bianchin C, Le Romancer M, Jonard L, Rostan MC, Rimokh R, Corbo L. BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms. J Cell Sci. 2003 Jul 15;116(Pt 14):2929-36. Epub 2003 May 27. PMID:12771185 doi:http://dx.doi.org/10.1242/jcs.00480
↑ Hong JW, Ryu MS, Lim IK. Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death. J Biol Chem. 2005 Jun 3;280(22):21256-63. Epub 2005 Mar 23. PMID:15788397 doi:10.1074/jbc.M500318200
↑ Miyata S, Mori Y, Tohyama M. PRMT1 and Btg2 regulates neurite outgrowth of Neuro2a cells. Neurosci Lett. 2008 Nov 14;445(2):162-5. doi: 10.1016/j.neulet.2008.08.065. Epub , 2008 Aug 28. PMID:18773938 doi:http://dx.doi.org/10.1016/j.neulet.2008.08.065

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OCA

[1] Morel AP, Sentis S, Bianchin C, Le Romancer M, Jonard L, Rostan MC, Rimokh R, Corbo L. BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms. J Cell Sci. 2003 Jul 15;116(Pt 14):2929-36. Epub 2003 May 27. PMID:12771185 doi:http://dx.doi.org/10.1242/jcs.00480

[2] Hong JW, Ryu MS, Lim IK. Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death. J Biol Chem. 2005 Jun 3;280(22):21256-63. Epub 2005 Mar 23. PMID:15788397 doi:10.1074/jbc.M500318200

[3] Miyata S, Mori Y, Tohyama M. PRMT1 and Btg2 regulates neurite outgrowth of Neuro2a cells. Neurosci Lett. 2008 Nov 14;445(2):162-5. doi: 10.1016/j.neulet.2008.08.065. Epub , 2008 Aug 28. PMID:18773938 doi:http://dx.doi.org/10.1016/j.neulet.2008.08.065

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3e9v

Crystal structure of human B-cell Translocation Gene 2 (BTG2)Crystal structure of human B-cell Translocation Gene 2 (BTG2)

Structural highlights

Function

Evolutionary Conservation

References

Contents

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3e9v

Crystal structure of human B-cell Translocation Gene 2 (BTG2)Crystal structure of human B-cell Translocation Gene 2 (BTG2)

Structural highlights

Function

Evolutionary Conservation

References

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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