3csq

Crystal and cryoEM structural studies of a cell wall degrading enzyme in the bacteriophage phi29 tailCrystal and cryoEM structural studies of a cell wall degrading enzyme in the bacteriophage phi29 tail

Structural highlights

3csq is a 4 chain structure with sequence from Bacillus phage phi29. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.8Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GP13_BPPH2 May serve as a plug to restrain the highly pressurized packaged genome and thus would be the first virion protein to contact the host cell wall, degrading the peptidoglycan layer and thereby facilitating viral genome entry into the host bacteria. Acts probably as a multifunctional enzyme that degrades N-acetylglucosamine polymers (in vitro) and cleaves the peptide cross-links of the host cell wall. Essential for the tail assembly.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Cohen DN, Erickson SE, Xiang Y, Rossmann MG, Anderson DL. Multifunctional roles of a bacteriophage phi 29 morphogenetic factor in assembly and infection. J Mol Biol. 2008 May 9;378(4):804-17. doi: 10.1016/j.jmb.2008.02.068. Epub 2008, Mar 7. PMID:18394643 doi:http://dx.doi.org/10.1016/j.jmb.2008.02.068
↑ Xiang Y, Morais MC, Cohen DN, Bowman VD, Anderson DL, Rossmann MG. Crystal and cryoEM structural studies of a cell wall degrading enzyme in the bacteriophage phi29 tail. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9552-7. Epub 2008 Jul 7. PMID:18606992

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OCA

[1] Cohen DN, Erickson SE, Xiang Y, Rossmann MG, Anderson DL. Multifunctional roles of a bacteriophage phi 29 morphogenetic factor in assembly and infection. J Mol Biol. 2008 May 9;378(4):804-17. doi: 10.1016/j.jmb.2008.02.068. Epub 2008, Mar 7. PMID:18394643 doi:http://dx.doi.org/10.1016/j.jmb.2008.02.068

[2] Xiang Y, Morais MC, Cohen DN, Bowman VD, Anderson DL, Rossmann MG. Crystal and cryoEM structural studies of a cell wall degrading enzyme in the bacteriophage phi29 tail. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9552-7. Epub 2008 Jul 7. PMID:18606992

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3csq

Crystal and cryoEM structural studies of a cell wall degrading enzyme in the bacteriophage phi29 tailCrystal and cryoEM structural studies of a cell wall degrading enzyme in the bacteriophage phi29 tail

Structural highlights

Function

Evolutionary Conservation

References

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3csq

Crystal and cryoEM structural studies of a cell wall degrading enzyme in the bacteriophage phi29 tailCrystal and cryoEM structural studies of a cell wall degrading enzyme in the bacteriophage phi29 tail

Structural highlights

Function

Evolutionary Conservation

References

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