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X-ray structure of Melon necrotic spot virusX-ray structure of Melon necrotic spot virus
Structural highlights
FunctionCAPSD_MNSV Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 32-35 nm in diameter, and consisting of 180 capsid proteins. Also acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe structure of melon necrotic spot virus (MNSV) was determined at 2.8 A resolution. Although MNSV is classified into the genus Carmovirus of the family Tombusviridae, the three-dimensional structure of MNSV showed a higher degree of similarity to tomato bushy stunt virus (TBSV), which belongs to the genus Tombusvirus, than to carnation mottle virus (CMtV), turnip crinkle virus (TCV) or cowpea mottle virus (CPMtV) from the genus Carmovirus. Thus, the classification of the family Tombusviridae at the genus level conflicts with the patterns of similarity among coat-protein structures. MNSV is one of the viruses belonging to the genera Tombusvirus or Carmovirus that are naturally transmitted in the soil by zoospores of fungal vectors. The X-ray structure of MNSV provides us with a representative structure of viruses transmitted by fungi. The structure of melon necrotic spot virus determined at 2.8 A resolution.,Wada Y, Tanaka H, Yamashita E, Kubo C, Ichiki-Uehara T, Nakazono-Nagaoka E, Omura T, Tsukihara T Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jan 1;64(Pt, 1):8-13. Epub 2007 Dec 20. PMID:18097092[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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