2yu0

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Solution structures of the PAAD_DAPIN domain of mus musculus interferon-activatable protein 205Solution structures of the PAAD_DAPIN domain of mus musculus interferon-activatable protein 205

Structural highlights

2yu0 is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

IFI5B_MOUSE May act as a transcriptional regulator in the myeloid lineage. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Dermott JM, Gooya JM, Asefa B, Weiler SR, Smith M, Keller JR. Inhibition of growth by p205: a nuclear protein and putative tumor suppressor expressed during myeloid cell differentiation. Stem Cells. 2004;22(5):832-48. PMID:15342947 doi:http://dx.doi.org/10.1634/stemcells.22-5-832
  2. ↑ Asefa B, Dermott JM, Kaldis P, Stefanisko K, Garfinkel DJ, Keller JR. p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation. FEBS Lett. 2006 Feb 20;580(5):1205-14. Epub 2006 Jan 20. PMID:16458891 doi:http://dx.doi.org/10.1016/j.febslet.2006.01.032
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