2ysh

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Solution structure of the WW domain from the human growth-arrest-specific protein 7, GAS-7Solution structure of the WW domain from the human growth-arrest-specific protein 7, GAS-7

Structural highlights

2ysh is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Disease

GAS7_HUMAN Note=A chromosomal aberration involving GAS7 is found in acute myeloid leukemia. Translocation t(11;17)(q23;p13) with MLL/HRX.

Function

GAS7_HUMAN May play a role in promoting maturation and morphological differentiation of cerebellar neurons.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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OCA