Solution structure of the CH domain from Human Neuron navigator 2Solution structure of the CH domain from Human Neuron navigator 2
Structural highlights
2yrn is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
NAV2_HUMAN Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs.[1][2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Ishiguro H, Shimokawa T, Tsunoda T, Tanaka T, Fujii Y, Nakamura Y, Furukawa Y. Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas. Oncogene. 2002 Sep 12;21(41):6387-94. PMID:12214280 doi:http://dx.doi.org/10.1038/sj.onc.1205751
↑Peeters PJ, Baker A, Goris I, Daneels G, Verhasselt P, Luyten WH, Geysen JJ, Kass SU, Moechars DW. Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53. Brain Res Dev Brain Res. 2004 Jun 21;150(2):89-101. PMID:15158073 doi:http://dx.doi.org/10.1016/j.devbrainres.2004.03.004
