2reo

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Crystal structure of human sulfotransferase 1C3 (Sult1C3) in complex with PAPCrystal structure of human sulfotransferase 1C3 (Sult1C3) in complex with PAP

Structural highlights

2reo is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.651Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ST1C3_HUMAN Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Meinl W, Donath C, Schneider H, Sommer Y, Glatt H. SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens. Food Chem Toxicol. 2008 Apr;46(4):1249-56. Epub 2007 Sep 6. PMID:17936463 doi:http://dx.doi.org/10.1016/j.fct.2007.08.040
  2. ↑ Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thornton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH. Structural and chemical profiling of the human cytosolic sulfotransferases. PLoS Biol. 2007 May;5(5):e97. PMID:17425406 doi:10.1371/journal.pbio.0050097

2reo, resolution 2.65Å

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OCA
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