2r2y

Crystal structure of the proteasomal Rpn13 PRU-domainCrystal structure of the proteasomal Rpn13 PRU-domain

Structural highlights

2r2y is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.7Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ADRM1_MOUSE Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Lamerant N, Kieda C. Adhesion properties of adhesion-regulating molecule 1 protein on endothelial cells. FEBS J. 2005 Apr;272(8):1833-44. PMID:15819879 doi:10.1111/j.1742-4658.2005.04613.x
↑ Schreiner P, Chen X, Husnjak K, Randles L, Zhang N, Elsasser S, Finley D, Dikic I, Walters KJ, Groll M. Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature. 2008 May 22;453(7194):548-52. PMID:18497827 doi:10.1038/nature06924

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OCA

[1] Lamerant N, Kieda C. Adhesion properties of adhesion-regulating molecule 1 protein on endothelial cells. FEBS J. 2005 Apr;272(8):1833-44. PMID:15819879 doi:10.1111/j.1742-4658.2005.04613.x

[2] Schreiner P, Chen X, Husnjak K, Randles L, Zhang N, Elsasser S, Finley D, Dikic I, Walters KJ, Groll M. Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature. 2008 May 22;453(7194):548-52. PMID:18497827 doi:10.1038/nature06924

[1]

[2]

2r2y

Crystal structure of the proteasomal Rpn13 PRU-domainCrystal structure of the proteasomal Rpn13 PRU-domain

Structural highlights

Function

Evolutionary Conservation

References

Contents

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2r2y

Crystal structure of the proteasomal Rpn13 PRU-domainCrystal structure of the proteasomal Rpn13 PRU-domain

Structural highlights

Function

Evolutionary Conservation

References

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