2nyu

Crystal Structure of Human FtsJ homolog 2 (E.coli) protein in complex with S-adenosylmethionineCrystal Structure of Human FtsJ homolog 2 (E.coli) protein in complex with S-adenosylmethionine

Structural highlights

2nyu is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.76Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

MRM2_HUMAN The disease may be caused by variants affecting the gene represented in this entry.

Function

MRM2_HUMAN S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Rorbach J, Boesch P, Gammage PA, Nicholls TJ, Pearce SF, Patel D, Hauser A, Perocchi F, Minczuk M. MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome. Mol Biol Cell. 2014 Sep 1;25(17):2542-55. PMID:25009282 doi:10.1091/mbc.E14-01-0014
↑ Lee KW, Bogenhagen DF. Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16 S ribosomal RNA (rRNA). J Biol Chem. 2014 Sep 5;289(36):24936-42. PMID:25074936 doi:10.1074/jbc.C114.581868

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OCA

[1] Rorbach J, Boesch P, Gammage PA, Nicholls TJ, Pearce SF, Patel D, Hauser A, Perocchi F, Minczuk M. MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome. Mol Biol Cell. 2014 Sep 1;25(17):2542-55. PMID:25009282 doi:10.1091/mbc.E14-01-0014

[2] Lee KW, Bogenhagen DF. Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16 S ribosomal RNA (rRNA). J Biol Chem. 2014 Sep 5;289(36):24936-42. PMID:25074936 doi:10.1074/jbc.C114.581868

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2nyu

Crystal Structure of Human FtsJ homolog 2 (E.coli) protein in complex with S-adenosylmethionineCrystal Structure of Human FtsJ homolog 2 (E.coli) protein in complex with S-adenosylmethionine

Structural highlights

Disease

Function

Evolutionary Conservation

References

Contents

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2nyu

Crystal Structure of Human FtsJ homolog 2 (E.coli) protein in complex with S-adenosylmethionineCrystal Structure of Human FtsJ homolog 2 (E.coli) protein in complex with S-adenosylmethionine

Structural highlights

Disease

Function

Evolutionary Conservation

References

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