2mv2

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Solution structure of Twinstar from Drosophila melanogastorSolution structure of Twinstar from Drosophila melanogastor

Structural highlights

2mv2 is a 1 chain structure with sequence from Drosophila melanogaster. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CADF_DROME Exhibits F-actin depolymerizing activity and regulates actin cytoskeleton dynamics (PubMed:21205790). Required for cytokinesis in both mitotic and meiotic cells and for aster migration and separation (PubMed:8522587). Promotes cell motility during ovary development and oogenesis (PubMed:11175754). During larval development, required for the cell rearrangement needed for formation of terminal filaments which are stacks of somatic cells that are important for the initiation of ovarioles (PubMed:11175754). Also required for border cell migration during oogenesis (PubMed:11175754). During border cell migration, required for actin turnover and lamellipodial protrusion (PubMed:21205790). Required for the establishment of planar cell polarity (PCP) where cells adopt a uniform orientation within the plane of an epithelium (PubMed:16571634). During establishment of PCP, required for the redistribution of the PCP core proteins fz and stan/fmi to the proximodistal cell boundary (PubMed:16571634). During pupal development, required for elongation of the retinal cell body and for rhabdomere morphogenesis (PubMed:18423434). Required for mushroom body neuroblast proliferation and axon growth (PubMed:15572110). Plays a role in the positive regulation of protein secretion (PubMed:20026655). Plays a role in the regulation of nuclear localization of actin (PubMed:22323606). Required for the maintenance of epithelial integrity by controlling cell junctions and is also necessary for cell survival and tissue growth through regulation of JNK and yki signaling (PubMed:27041568).[1] [2] [3] [4] [5] [6] [7] [8] [9]

References

  1. ↑ Chen J, Godt D, Gunsalus K, Kiss I, Goldberg M, Laski FA. Cofilin/ADF is required for cell motility during Drosophila ovary development and oogenesis. Nat Cell Biol. 2001 Feb;3(2):204-9. PMID:11175754 doi:http://dx.doi.org/10.1038/35055120
  2. ↑ Ng J, Luo L. Rho GTPases regulate axon growth through convergent and divergent signaling pathways. Neuron. 2004 Dec 2;44(5):779-93. PMID:15572110 doi:http://dx.doi.org/10.1016/j.neuron.2004.11.014
  3. ↑ Blair A, Tomlinson A, Pham H, Gunsalus KC, Goldberg ML, Laski FA. Twinstar, the Drosophila homolog of cofilin/ADF, is required for planar cell polarity patterning. Development. 2006 May;133(9):1789-97. Epub 2006 Mar 29. PMID:16571634 doi:http://dx.doi.org/10.1242/dev.02320
  4. ↑ Pham H, Yu H, Laski FA. Cofilin/ADF is required for retinal elongation and morphogenesis of the Drosophila rhabdomere. Dev Biol. 2008 Jun 1;318(1):82-91. doi: 10.1016/j.ydbio.2008.03.006. Epub 2008, Mar 15. PMID:18423434 doi:http://dx.doi.org/10.1016/j.ydbio.2008.03.006
  5. ↑ von Blume J, Duran JM, Forlanelli E, Alleaume AM, Egorov M, Polishchuk R, Molina H, Malhotra V. Actin remodeling by ADF/cofilin is required for cargo sorting at the trans-Golgi network. J Cell Biol. 2009 Dec 28;187(7):1055-69. doi: 10.1083/jcb.200908040. Epub 2009, Dec 21. PMID:20026655 doi:http://dx.doi.org/10.1083/jcb.200908040
  6. ↑ Zhang L, Luo J, Wan P, Wu J, Laski F, Chen J. Regulation of cofilin phosphorylation and asymmetry in collective cell migration during morphogenesis. Development. 2011 Feb;138(3):455-64. doi: 10.1242/dev.046870. PMID:21205790 doi:http://dx.doi.org/10.1242/dev.046870
  7. ↑ Dopie J, Skarp KP, Rajakyla EK, Tanhuanpaa K, Vartiainen MK. Active maintenance of nuclear actin by importin 9 supports transcription. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):E544-52. doi:, 10.1073/pnas.1118880109. Epub 2012 Feb 9. PMID:22323606 doi:http://dx.doi.org/10.1073/pnas.1118880109
  8. ↑ Ko C, Kim YG, Le TP, Choi KW. Twinstar/cofilin is required for regulation of epithelial integrity and tissue growth in Drosophila. Oncogene. 2016 Sep 29;35(39):5144-54. doi: 10.1038/onc.2016.46. Epub 2016 Apr 4. PMID:27041568 doi:http://dx.doi.org/10.1038/onc.2016.46
  9. ↑ Gunsalus KC, Bonaccorsi S, Williams E, Verni F, Gatti M, Goldberg ML. Mutations in twinstar, a Drosophila gene encoding a cofilin/ADF homologue, result in defects in centrosome migration and cytokinesis. J Cell Biol. 1995 Dec;131(5):1243-59. PMID:8522587
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