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Structure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domainStructure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domain
Structural highlights
FunctionPublication Abstract from PubMedImmunoevasins are key proteins used by viruses to subvert host immune responses. Determining their high-resolution structures is key to understanding virus-host interactions toward the design of vaccines and other antiviral therapies. Mouse cytomegalovirus encodes a unique set of immunoevasins, the m02-m06 family, that modulates major histocompatibility complex class I (MHC-I) antigen presentation to CD8+ T cells and natural killer cells. Notwithstanding the large number of genetic and functional studies, the structural biology of immunoevasins remains incompletely understood, largely because of crystallization bottlenecks. Here we implement a technology using sparse nuclear magnetic resonance data and integrative Rosetta modeling to determine the structure of the m04/gp34 immunoevasin extracellular domain. The structure reveals a beta fold that is representative of the m02-m06 family of viral proteins, several of which are known to bind MHC-I molecules and interfere with antigen presentation, suggesting its role as a diversified immune regulation module. The structure of mouse cytomegalovirus m04 protein obtained from sparse NMR data reveals a conserved fold of the m02-m06 viral immune modulator family.,Sgourakis NG, Natarajan K, Ying J, Vogeli B, Boyd LF, Margulies DH, Bax A Structure. 2014 Sep 2;22(9):1263-73. doi: 10.1016/j.str.2014.05.018. Epub 2014, Aug 7. PMID:25126960[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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