2m35

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NMR study of k-Ssm1aNMR study of k-Ssm1a

Structural highlights

2m35 is a 1 chain structure with sequence from Scolopendra subspinipes. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR, 20 models
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TX31A_SCOMU This toxin inhibits voltage-gated potassium channel currents in DRG neurons (IC(50)=44.2 nM). In vivo, insects injected with this toxin showed signs of neurotoxicity including twitching, paralysis, and body contraction.[1]

References

  1. Yang S, Liu Z, Xiao Y, Li Y, Rong M, Liang S, Zhang Z, Yu H, King GF, Lai R. Chemical punch packed in venoms makes centipedes excellent predators. Mol Cell Proteomics. 2012 Sep;11(9):640-50. PMID:22595790 doi:10.1074/mcp.M112.018853
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