2kxc

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1H, 13C, and 15N Chemical Shift Assignments for IRTKS-SH3 and EspFu-R47 complex1H, 13C, and 15N Chemical Shift Assignments for IRTKS-SH3 and EspFu-R47 complex

Structural highlights

2kxc is a 2 chain structure with sequence from Escherichia coli O157:H7 and Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BI2L1_HUMAN May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.[1] [2] [3]

References

  1. ↑ Millard TH, Dawson J, Machesky LM. Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties. J Cell Sci. 2007 May 1;120(Pt 9):1663-72. Epub 2007 Apr 12. PMID:17430976 doi:http://dx.doi.org/jcs.001776
  2. ↑ Vingadassalom D, Kazlauskas A, Skehan B, Cheng HC, Magoun L, Robbins D, Rosen MK, Saksela K, Leong JM. Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6754-9. doi:, 10.1073/pnas.0809131106. Epub 2009 Apr 6. PMID:19366662 doi:10.1073/pnas.0809131106
  3. ↑ Aitio O, Hellman M, Skehan B, Kesti T, Leong JM, Saksela K, Permi P. Enterohaemorrhagic Escherichia Coli Exploits a Tryptophan Switch to Hijack Host F-Actin Assembly. Structure. 2012 Aug 21. PMID:22921828 doi:http://dx.doi.org/10.1016/j.str.2012.07.015
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OCA
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