2kvg

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Structure of the three-Cys2His2 domain of mouse testis zinc finger proteinStructure of the three-Cys2His2 domain of mouse testis zinc finger protein

Structural highlights

2kvg is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ZBT32_MOUSE DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor (By similarity). Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells.[1]

References

  1. ↑ Tang CJ, Chuang CK, Hu HM, Tang TK. The zinc finger domain of Tzfp binds to the tbs motif located at the upstream flanking region of the Aie1 (aurora-C) kinase gene. J Biol Chem. 2001 Jun 1;276(22):19631-9. Epub 2001 Mar 12. PMID:11279021 doi:http://dx.doi.org/10.1074/jbc.M100170200
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OCA
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