2kmi

MESD(12-155), The Core Structural Domain of MESD that Is Essential for Proper Folding of LRP5/6MESD(12-155), The Core Structural Domain of MESD that Is Essential for Proper Folding of LRP5/6

Structural highlights

2kmi is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MESD_MOUSE Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Hsieh JC, Lee L, Zhang L, Wefer S, Brown K, DeRossi C, Wines ME, Rosenquist T, Holdener BC. Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity. Cell. 2003 Feb 7;112(3):355-67. PMID:12581525
↑ Chen J, Liu CC, Li Q, Nowak C, Bu G, Wang J. Two Structural and Functional Domains of MESD Required for Proper Folding and Trafficking of LRP5/6. Structure. 2011 Mar 9;19(3):313-23. PMID:21397183 doi:10.1016/j.str.2011.01.010

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OCA

[1] Hsieh JC, Lee L, Zhang L, Wefer S, Brown K, DeRossi C, Wines ME, Rosenquist T, Holdener BC. Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity. Cell. 2003 Feb 7;112(3):355-67. PMID:12581525

[2] Chen J, Liu CC, Li Q, Nowak C, Bu G, Wang J. Two Structural and Functional Domains of MESD Required for Proper Folding and Trafficking of LRP5/6. Structure. 2011 Mar 9;19(3):313-23. PMID:21397183 doi:10.1016/j.str.2011.01.010

[1]

[2]

2kmi

MESD(12-155), The Core Structural Domain of MESD that Is Essential for Proper Folding of LRP5/6MESD(12-155), The Core Structural Domain of MESD that Is Essential for Proper Folding of LRP5/6

Structural highlights

Function

Evolutionary Conservation

References

Contents

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2kmi

MESD(12-155), The Core Structural Domain of MESD that Is Essential for Proper Folding of LRP5/6MESD(12-155), The Core Structural Domain of MESD that Is Essential for Proper Folding of LRP5/6

Structural highlights

Function

Evolutionary Conservation

References

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